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OCR: tines and HDL is synthesised in the liver and inte secreted as bilayers of apo AI, apo All ar rom two phospholipid. HDL acquires cholesterol Ways major sources. During the catabolic path ponents described earlier, lipoprotein surface cor become (particularly unesterified cholesterol) th re redundant as the particle size decreases cellular transferred to HDL. Additionally, excess ticles. The cholesterol is picked up by lipophilic pa T). The he enzyme cholesterol is subsequently esterified by lecithin-cholesterol acyltransferase (LCA moves hydrophobic cholesterol ester that resul to the into the core of the HDL particle, leadin formation of a spherical particle (Fig. 6.